Impaired regulatory T cell function in germ-free mice
نویسندگان
چکیده
منابع مشابه
Impaired function of regulatory T-cells in hypersensitivity pneumonitis.
Hypersensitivity pneumonitis (HP) is characterised by lung lymphocytosis. Most individuals exposed to HP antigens remain asymptomatic. The mechanisms involved in the impaired immune tolerance leading to HP are unclear. Normally, T-regulatory (Treg)-cells control the immune response. The aim of the present study was to determine whether Treg-cell suppressive function deficiency can explain the u...
متن کاملTitle: Impaired Function of Regulatory T cells in Hypersensitivity Pneumonitis
Hypersensitivity pneumonitis (HP) is characterized by a lung lymphocytosis. Most individuals exposed to HP antigens remain asymptomatic. The mechanisms involved in the impaired immune tolerance leading to HP are unclear. Normally, T regulatory cells (Treg) control the immune response. Could Treg suppressive function deficiency explain the uncontrolled inflammation in HP? Bronchoalveolar lavage ...
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Elderly organ transplant recipients represent a fast growing segment of patients on the waiting list. We examined age-dependent CD4(+) T-cell functions in a wild-type (WT) and a transgenic mouse transplant model and analyzed the suppressive function of old regulatory T-cells. We found that splenocytes of naïve old B6 mice contained significantly higher frequencies of T-cells with an effector/me...
متن کاملNovel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis
OBJECTIVE Premature senescence of lymphocytes is a hallmark of inflammatory rheumatic diseases such as rheumatoid arthritis (RA). Early T-cell aging affects conventional T-cells but is presumably not limited to this cell population; rather it might also occur in the regulatory T-cells (Tregs) compartment. In RA, Tregs fail to halt aberrant immune reactions and disease progression. Whether this ...
متن کاملThe plasticity of regulatory T cell function.
Regulatory T cells (T(regs)) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. Whereas T(regs) possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any interrelationship or cross-regulatory mechanisms exist to orchestrate and control their utilization is unknown. In this study, we assessed...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2006
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200535244